韩国社区药房的药物治疗方案复杂性和患者报告的不良药物事件:一个跨部门研究
1College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea.
Pharmacy (Basel, Switzerland)
|February 20, 2026
概括
药物治疗方案的复杂性与较少报告的不良药物事件 (ADEs) 有关. 老年人和那些复杂治疗方案的人可能会低于报告ADEs,强调需要以患者为中心的策略来改善检测.
科学领域:
- 药理学 药理学是指药理学的学科.
- 患者安全 患者安全
- 医疗保健服务研究 医疗服务研究
背景情况:
- 关于药物治疗方案复杂性和患者报告的不良药物事件 (ADEs) 之间的关系的证据有限.
- 了解这种关联对于改善社区药房环境中的患者安全和药物管理至关重要.
研究的目的:
- 检查使用社区药房服务的成年人中药物治疗方案复杂性和患者报告的不良反应之间的关联.
- 确定影响药物治疗方案复杂性的因素和ADE报告的预测因素.
主要方法:
- 在201名在韩国社区药房有处方经验的成年人中进行了横截面调查.
- 收集的数据包括药物治疗方案复杂性指数-韩国 (MRCI-K) 评分,药物服药,ADE报告,并发症,多药和人口统计数据.
- 使用多变量回归模型来评估ADE报告的复杂性决定因素和预测因素.
主要成果:
- 超过一半 (50.2%) 的参与者在过去一个月中报告了至少一次ADE.
- 多药性,并发性疾病和多剂量开放与更高的治疗方案复杂性有关.
- 较高的MRCI-K得分和年龄较大与较低的报道ADEs的几率有关 (OR = 0.95和0.98,分别).
结论:
- 增加药物治疗方案的复杂性和年龄的增加与药物不良事件报告的减少有关.
- 这表明,在这些患者群体中,可能没有充分认识到ADEs.
- 以患者为中心的策略对于提高复杂药物治疗方案的个体中ADE识别至关重要.
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