皮下与肌肉内施用雌激素的比较,用于女性化性别确认激素治疗
Abby C Poage1, Jordan M Rowe1,2, Mary Beth A Dameron1
1University Health Truman Medical Center, Kansas City, MO 64108, USA.
Pharmacy (Basel, Switzerland)
|February 20, 2026
概括
皮下 (SC) 和肌内 (IM) 雌激素的使用在跨性别患者在6个月内达到治疗水平方面表现出类似的疗效. 在探索性分析中,肌肉内注射与更高的雌激素度有关.
科学领域:
- 内分泌学 在内分泌学.
- 肯定性别的护理.
- 药理学 药理学是指药理学的学科.
背景情况:
- 雌激醇的使用对于性别肯定激素治疗至关重要.
- 皮下 (SC) 和肌内 (IM) 途径是输送雌激素的常见方法.
- 优化雌醇的使用可确保治疗疗效和患者的安全.
研究的目的:
- 为了比较SC与IM雌激素的疗效,在患有性别不一致或性别失调症的患者中.
- 为了评估治疗性雌激醇水平在给药后6个月的达到.
- 探索雌醇水平和注射教育影响的差异.
主要方法:
- 70名LGBTQ专科诊所成年患者的回顾性队列研究.
- 在2018年10月至2024年12月期间,SC与IM雌激素的比较.
- 主要终点:6个月治疗性雌激素水平;次要:3,6,9,12个月和注射教育水平.
主要成果:
- 在SC和IM组之间,在6个月内达到治疗性雌激素水平没有显著差异.
- 探索性分析表明,在IM给药时,测量中的雌激素度更高.
- 药剂师主导的注射教育也得到了评估.
结论:
- SC和IM两种类型的雌激素都有效地达到性别不一致性/性别失调症的治疗水平.
- IM雌激素可能导致更高的循环度,需要进一步调查.
- 个性化雌激素的使用策略可能是有益的.
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