评估巴林2型糖尿病患者和没有2型糖尿病患者的可塑剂水平,酸盐和双醇
Edwina Brennan1, Priya Das1, Pearl Wasif1
1School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen 15503, Bahrain.
Journal of xenobiotics
|February 20, 2026
概括
巴林的塑化剂暴露显示了酸盐水平的升高,2型糖尿病 (T2D) 患者在塑化剂,年龄和体重指数 (BMI) 之间表现出改变的关系. 这些发现表明T2D中的差异性暴露-反应关系.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 具有内分泌干扰潜力的可塑化剂广泛存在,并与肥胖和2型糖尿病 (T2D) 有关.
- 中东地区报告有较高的塑化剂含量,但巴林没有数据,其中T2D患病率为15%.
研究的目的:
- 调查巴林2型糖尿病患者和健康对照者的塑化剂暴露水平.
- 为了检查尿液增塑剂水平,T2D和代谢参数 (如BMI和HbA1c) 之间的关联.
主要方法:
- 一项观察性研究分析了24小时的尿液增塑剂水平,使用液态染色学双重质谱法 (LC-MS/MS).
- 参与者包括60名2型糖尿病患者和96名健康对照.
- 使用相关性和通用线性模型 (GLM) 分析来评估关系.
主要成果:
- 与对照人群相比,T2D患者的尿液中单3-碳基甲酸盐 (MCPP),单2-乙基-5-碳基甲酸盐 (MECPP),单甲酸盐 (MEP) 和双S (BPS) 的水平较低.
- 这些差异被体重指数 (BMI) 和年龄所混,在T2D组中,年龄和BMI的影响是逆转的.
- 单-n-丁酸盐 (MnBP) 水平在T2D中较高,但这种关联与年龄有关.
结论:
- 巴林的酸盐含量较高,与区域数据一致.
- 与对照人群相比,在T2D患者中存在塑化剂,年龄和BMI之间的不同暴露-反应关系.
- 这些发现凸显了巴林人口在塑化剂暴露和代谢健康之间复杂的相互作用.
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