相关实验视频

Updated: Feb 22, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

内分泌干扰化学物质对胚胎反复植入失败的影响:叙述性审查

Anastasios Potiris¹, Panagiotis Antsaklis², Panagiotis Christopoulos³

¹Third Department of Obstetrics and Gynecology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Journal of xenobiotics

|February 20, 2026

概括

内分泌干扰化学物质 (EDCs) 可能导致辅助生殖的复发性植入失败 (RIF),即使是高质量的胚胎. 减少环境化学物质暴露可以改善试管婴儿的结果,并个性化RIF治疗.

科学领域:

生殖医学生殖医学
环境健康环境健康
内分泌学在内分泌学.

背景情况:

反复植入失败 (RIF) 是辅助生殖的一个持续挑战,尽管使用高质量的胚胎,但影响结果.
内分泌干扰化学物质 (EDC) 是广泛存在的环境物质,可以干扰荷尔蒙调节.
EDCs可能会对关键的植入机制产生负面影响,包括子宫内膜受体和免疫耐受性.

研究的目的:

审查目前对内分泌干扰化学物质 (EDC) 如何导致复发性植入失败 (RIF) 的理解.
探索EDC暴露与辅助生殖技术 (ART) 中不良植入结果相关的分子机制.
突出EDC作为RIF的潜在可修改风险因素.

主要方法:

这篇叙事综述综合了关于EDC效应的实验研究的发现.
它还结合了临床和流行病学数据,将EDC水平与ART成功率联系在一起.
该审查侧重于受EDCs影响的与植入相关的分子通路.

主要成果:

实验数据显示EDCs改变子宫内膜基因表达,炎症反应和早期胚胎发育.
临床研究将更高的EDC身体负担与ART周期中植入率的降低联系起来.
EDCs可以破坏关键过程,如类固醇激素信号传递和母胎免疫耐受性.

结论:

对内分泌干扰化学物质 (EDC) 的环境暴露是导致复发植入失败 (RIF) 的重要因素.
了解这些分子联系为RIF预防和个性化ART策略提供了新的途径.
识别和减轻EDC暴露可能是改善生育治疗成功的可修改风险因素.

关键词:

艺术艺术艺术艺术宫内膜的受体性宫内膜的受体性环境暴露环境暴露环境暴露表观遗传修饰是一种表观遗传修饰.激素受体的信号传递方式免疫调节免疫调节生殖毒理学生殖毒理学

更多相关视频

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

Methods to Test Endocrine Disruption in Drosophila melanogaster

Methods to Test Endocrine Disruption in Drosophila melanogaster

Published on: July 3, 2019

相关概念视频

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...