血清25(OH) D度与儿科患者的临床特征之间的关联
Maria Nicolae1, Sorin Deacu2, Cristina Maria Mihai3
1Doctoral School, Faculty of General Medicine, "Ovidius" University, 900470 Constanta, Romania.
Reports (MDPI)
|February 20, 2026
概括
住院患有呼吸道感染的儿童的维生素D水平较低,与住院时间较长和更严重的疾病有关. 确保足够的维生素D可以改善儿科呼吸道感染的结果.
科学领域:
- 儿科医学 儿科医学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 维生素D在免疫功能和炎症中起着至关重要的作用,特别是在呼吸道感染中.
- 低维他命素D在儿童中普遍存在,尽管补充剂,对其对东欧儿童呼吸道感染住院结果的影响的数据有限.
研究的目的:
- 研究患有急性呼吸道感染 (ARTI) 的儿科患者的维生素D状况和住院结果之间的关联.
主要方法:
- 一组由400名因ARTI住院的儿科患者组成的队列,根据血清25(OH) D水平,被分为正常维生素D (NVD) 和低维生素D (LVD) 组.
- 使用非参数方法进行连续变量的组间比较.
主要成果:
- 在LVD组的儿童经历了显著更长的住院时间 (4.68天 vs 2.89天) 和更高的疾病严重程度标志物,包括临床得分,CRP水平和氧气治疗需求.
- 与NVD组 (平均47.60 ng/mL) 相比,LVD组的血清维生素D度较低 (平均21.63 ng/mL).
- 在LVD组中,发烧更频繁 (61.0%对32.0%),并且在血清25(OH) D和住院时间和严重程度之间发现了反向相关性.
结论:
- 儿童血清中低25(OH) D度与急性呼吸道感染的严重程度增加和长时间住院有关.
- 这些发现凸显了足够的维生素D水平对儿科呼吸系统健康的重要性,并暗示了优化维生素D状态的潜在好处.
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