与药物不良反应相关的住院和药物不良事件及其与老年人短期和长期健康结果的关联
Juliane Frydenlund1, David J Williams2, Frank Moriarty3
1Data Science Centre, School of Population Health, RCSI University of Medicine and Health Science, D02 YN77 Dublin, Ireland.
Geriatrics (Basel, Switzerland)
|February 20, 2026
概括
老年人的药物不良反应 (ADR) 和不良药物事件 (ADE) 并没有显著影响随着时间的推移生活质量或医疗保健访问的变化. 然而,ADE与较差的长期健康结果有关.
科学领域:
- 老年学是一门学科.
- 药物监督 药物监督 药物监督
- 医疗保健服务研究 医疗服务研究
背景情况:
- 调查药物不良反应 (ADR) 和药物不良事件 (ADE) 对老年人的健康结果的影响.
- 检查ADR相关住院和初级保健ADEs与健康相关生活质量 (HRQOL) 变化,功能下降和A&E访问之间的关联.
- 利用爱尔兰的两个前性队列研究:ADAPT (N=230) 和CPCR (N=605).
研究的目的:
- 确定与ADR相关的住院或初级保健ADEs是否与老年人HRQOL的纵向变化,功能衰退和A&E访问有关.
- 评估ADR和ADE对特定健康结果的短期和长期影响.
- 为了调整关键的混因素,包括年龄,性别,并发症和多药性.
主要方法:
- 前性队列研究 (ADAPT和CPCR) 使用基线和随访健康结果问卷.
- 在基线评估与ADR相关的入院和ADEs.
- 多变量回归分析 (线性,后勤,顺序后勤) 检查ADR/ADE与HRQOL变化,功能衰退和A&E访问之间的关联.
主要成果:
- 在短期 (3个月) 中,无论ADR状态如何,在ADAPT队列中,脆弱性增加,A&E访问减少.
- 在长期 (24个月) 观察中,ADE和非ADE组的CPCR队列中,HRQOL下降,功能衰退和A&E访问增加.
- 虽然ADE患者的基线HRQOL较低,功能衰退较大,但经历ADR或ADE并没有与调整后这些结果随时间变化显著相关.
结论:
- 在ADR和非ADR组之间没有观察到医疗负担的短期显著差异.
- 药物不良事件 (ADEs) 与老年人的长期健康结果较差有关.
- 该研究强调了考虑ADE的长期后果的重要性,尽管缺乏与特定结果措施随时间变化的显著关联.
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