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原发性冷漠性急性原核细胞白血病

Breanne Wolfenbarger¹, Daley Morera², Brandol Wolfenbarger²

¹Alabama College of Osteopathic Medicine, Dothan, AL 36303, USA.

Hematology reports

|February 20, 2026

概括

本病例报告详细介绍了一种不寻常的,进展缓慢的急性肌肉细胞白血病 (APL),具有特定的遗传突变. 早期诊断和治疗导致缓解,扩大了对APL表现的理解.

科学领域:

血液学血液学血液学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

急性肌肉细胞白血病 (APL) 是一种攻击性的肌肉细胞白血病亚型.
APL是由PML::RARA融合基因定义的,并且经常表现为严重的凝血病.
由于疾病的典型快速进展,及时诊断和治疗至关重要.

研究的目的:

报告一种非典型的新型急性前兆细胞白血病病例,其临床过程不稳定.
强调在非经典呈现的情况下考虑APL的重要性.
扩大已知APL的临床范围.

主要方法:

一个37岁的女性病例报告,患有超过一年的不明原因的泛细胞衰竭.
骨髓活检用形态学,流量细胞计,细胞遗传学 (t(15;17) 和分子 (PML::RARA,TP53损失,ETV6突变) 分析.
使用全转网红酸和三氧化的诱导疗法.

主要成果:

这位患者呈现出惰的泛细胞衰竭,与典型的侵略性APL相反.
骨髓发现证实了经典的APL与PML::RARA融合,以及TP53损失和ETV6突变.
用全转网红酸和三氧化治疗实现了血液学缓解.

结论:

这一案例代表了以前未经证实的 de novo APL 的一种惰形式.
非典型的临床表现需要对骨髓形态和免疫类型特征进行彻底评估.
进一步描述这些病例可以完善APL诊断,并指导个性化治疗.

关键词:

PML::RARA:拉拉拉拉拉拉拉拉拉拉拉拉拉急性促细胞白血病急性促细胞白血病一个无色的APL.

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