流体过载相关的大型B细胞淋巴瘤呈现为孤立的肺溢液
Kevin Leeper1, Lauren Borecky1, Mojtaba Akhtari2
1Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.
Hematology reports
|February 20, 2026
概括
流体过载相关的大B细胞淋巴瘤是一种罕见的疾病,可以模仿其他淋巴瘤. 识别其独特的特征对于准确诊断和治疗流体过载患者至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 主要流血性淋巴瘤不常见,在诊断上具有挑战性.
- 流体过载相关的大B细胞淋巴瘤 (FO-LBCL) 是一个新认可的实体.
- 应考虑在输出性淋巴瘤中使用FO-LBCL,特别是在患有流体过载的老年患者中.
研究的目的:
- 报告FO-LBCL病例,为有限的文献做出贡献.
- 要突出FO-LBCL与其他原发性输液淋巴瘤的区别特征.
- 强调在差异诊断中考虑FO-LBCL的重要性.
主要方法:
- 一个77岁的男性患有末期脏病和心力衰竭的病例报告.
- 胸腔液细胞学和免疫类型的分析 (CD20,Pax-5,CD79a,CD45,MUM1,BCL2,BCL6). 检查了多发性肺液细胞学和免疫类型的分析.
- 排除人类疹病毒-8和爱斯坦-巴尔病毒;用PET-CT进行分期.
主要成果:
- 胸腔液显示了大型非典型的淋巴细胞的片段.
- 免疫类型定型对B细胞标记物和MUM1,BCL2,BCL6 (弱) 呈阳性.
- 患者被诊断为FO-LBCL,接受化疗免疫治疗,三个月后去世.
结论:
- FO-LBCL是基于输液的淋巴瘤的一个重要的新考虑因素.
- 它可以被误诊为原发性输液淋巴瘤或其他扩散的大B细胞淋巴瘤.
- 人类疹病毒-8阴性输液淋巴瘤在老年人中,免疫能力强,没有结节参与的患者需要考虑FO-LBCL.
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