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为USP16和HDAC6指-乌比基结合域开发双化学探针

Madhushika Silva1, Mandeep Mann1, Bijan Mirabi2

  • 1Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

Journal of medicinal chemistry
|February 20, 2026
PubMed
概括

研究人员开发了SGC-UBD1031,一种针对USP16-UBD的化学探针. 这种探测器有助于通过破坏细胞中的蛋白质相互作用来研究泛素特异性酶16 (USP16) 的生物学作用.

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Nucleosome Remodeling02:54

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Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
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