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Updated: May 5, 2026

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在接受尼卡米辛治疗的老鼠中,全身胆酸水平急剧增加

Fumika Yokoyama1, Riho Yamada1, Hiromichi Yamazaki1

  • 1Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan.

Bioscience, biotechnology, and biochemistry
|February 20, 2026
PubMed
概括

在大鼠中,突尼卡米辛 (TM) 暴露增加了胆酸 (BA) 循环和肝脏ER压力标志物. 这表明,内等质网膜应激会导致改变BA代谢和全身循环.

关键词:
胆汁酸循环 胆汁酸循环鼠类 鼠类 鼠类 鼠类 鼠类突尼西亚胺氨酸 (Tunicamycin) 是一种

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Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
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