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性别差异在CKD并发症的发展中
Gianmarco Lombardi1, Elisa De Tomi1, Chiara Lenoci1
1Section of Nephrology, Department of Medicine, Università degli Studi di Verona, Verona, Italy.
概括
患有慢性脏病 (CKD) 的男性体验血红蛋白和酸化的下降速度更快,甲状腺上腺激素的增加更大. 然而,这些特定于性别的CKD并发症模式并没有影响死亡风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 关于慢性病 (CKD) 并发症的性别差异的证据有限,通常依赖横截面数据.
- 本研究通过纵向检查CKD并发症参数和性别特异性差异来弥补这一差距.
研究的目的:
- 纵向评估CKD并发症的临床和生化标志物.
- 识别和比较CKD并发症的性别特异性轨迹.
- 调查这些并发症与男性和女性死亡率的关联.
主要方法:
- 对CRIC队列的回顾性分析,随访10年.
- 包括成年人的基线eGFR为20-70毫升/分钟/1.73米2.
- 使用混合效应模型和Cox死亡率回归的血红蛋白,CO2,,,PTH和SBP的纵向评估,用性别分层分析.
主要成果:
- 男人患贫血,酸症,高血症和甲状腺功能障碍症的患病率更高;女性患高酸血症的患病率更高.
- 从长度上看,EGFR的恶化与Hb,CO2,SBP的下降以及K+,酸盐和iPTH的增加相关.
- 与女性相比,男性的Hb和CO2下降幅度更大,iPTH的上升幅度更大. 男性的全因死亡率更高.
结论:
- 在CKD并发症的进展中存在显著的性别差异,男性在关键参数中经历了更快的变化.
- 尽管并发症轨迹不同,但性别并没有影响与这些特定CKD并发症相关的死亡风险.
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