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Updated: Feb 22, 2026

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
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一个PI3Kδ-Foxo1-FasL信号放大环重新连接CD4+T细胞信号和分化

Dominic P Golec1,2, Pedro H Gazzinelli-Guimaraes3, Daniel Chauss4

  • 1Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD, USA.

The Journal of experimental medicine
|February 20, 2026
PubMed
概括

激活PI3Kδ突变会通过破坏T辅助细胞分化导致免疫缺陷. 阻断FasL使T细胞功能正常化,揭示了Fas-FasL信号作为PI3Kδ驱动的免疫失调的关键因素.

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