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周产期暴露于delta-9-tetrahydrocannabinol (THC) 改变了怀思达大鼠的目标导向行为和多巴胺功能

Monica S Carbajal¹, Rebecca C Crenshaw¹, Victoria E Williams¹

¹Department of Psychology, University of Memphis, Memphis, TN, 38152, USA.

Psychopharmacology

|February 20, 2026

概括

在大鼠中,周产期暴露于delta-9-tetrahydrocannabinol (THC) 降低了对奖励的动机,特别是在雄性中. 这表明,产前大麻使用对行为和奖励处理有潜在的长期影响.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
药理学药理学是指药理学的学科.

背景情况:

怀孕期间大麻的使用很普遍,许多女性认为它是安全的,因为它的"自然"起源.
临床证据将围产期大麻暴露与后代的外部化行为联系在一起.
临床前研究通常集中在delta-9-tetrahydrocannabinol (THC),主要的精神活性成分,它很容易穿过胎盘屏障.

研究的目的:

通过操作程序,研究周产期THC暴露对成年后代的动机和冲动性的影响.
评估与奖励寻求和行动控制相关的行为变化.

主要方法:

从繁殖前到产后的第14天,母母被给予0或5毫克/公斤/天的THC.
操作任务,包括高速率 (DRH) 和低速率 (DRL) 的差强化,用于测量动机和冲动行为.
在中部前额叶皮层 (mPFC) 和核 (NAc) 中的多巴胺 (DA) 功能通过体内电压测量进行了评估.

主要成果:

周产期THC暴露在DLR 15s任务中对冲动行为影响最小.
在男性中,THC暴露降低了DLR15s爆发反应和完成的试验,在男性中获得了强化剂.
在DRH任务中观察到杆压力下降,男性的强化器较少.
基线DA释放不受影响,但NAc中对可卡因的多巴胺反应减弱.

结论:

周产期THC暴露减少了在高精力任务中获得奖励的动机,对男性的影响可能更大.
观察到的"激励状态"可能来自强化器值.
这些发现突出了产前大麻暴露对奖励处理的潜在神经生物学后果.

关键词:

激发性综合征中皮层临界多巴胺.发育神经毒理学发展神经毒理学口服THCTHC口服THC是什么意思

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