青少年大麻使用和精神病,双极性,抑郁和焦虑障碍的风险
Kelly C Young-Wolff1,2, Catherine A Cortez1, Stacey E Alexeeff1
1Division of Research, Kaiser Permanente Northern California, Pleasanton.
JAMA health forum
|February 20, 2026
概括
青少年使用大麻显著增加患精神病,双相情感,抑郁症和焦虑症的风险. 鉴于大麻可获得性的增加,早期干预和保护性政策至关重要.
科学领域:
- 青少年精神病学 青少年精神病学
- 心理健康研究 心理健康研究
- 大麻使用流行病学
背景情况:
- 大麻日益普及和社会接受,引发了人们对青少年心理健康的担忧.
- 之前的研究将青少年大麻使用与精神病症状联系起来,但对被诊断的疾病的大型纵向研究有限.
研究的目的:
- 调查青少年大麻使用与患精神病,双相情感,抑郁和焦虑障碍的风险之间的联系.
- 为了评估这些风险在青春期和成年后的年轻人.
主要方法:
- 一项对青少年 (13-17岁) 的队列研究,从2016-2023年对大麻使用进行查.
- 随访到25岁,使用电子健康记录进行诊断 (ICD代码).
- 考克斯比例危险回归调整为共变量.
主要成果:
- 青少年使用大麻与精神病 (AHR, 2.19),双相情感 (AHR, 2.01),抑郁 (AHR, 1.34) 和焦虑症 (AHR, 1.24) 的风险更高有关.
- 与抑郁和焦虑障碍的关联随着年龄的增长而减少.
- 经过对先前的精神疾病进行调整后,结果仍然显著.
结论:
- 青少年吸食大麻与发生精神疾病的风险增加有关,特别是精神病和双相情感.
- 这些发现支持了临床,教育和政策干预措施的需要,以减轻风险.
- 这项研究在扩大大麻合法化的背景下很重要.
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