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Updated: Jul 4, 2026

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从Withania coagulans中鉴定出具有预测多目标结合亲缘关系的两种特类:一个体外和体内研究

Hansa Gul1, Nasir Assad2, Zahida Nasreen1

  • 1Department of Zoology, University of Mianwali, Mianwali, Punjab, Pakistan.

PloS one
|February 20, 2026
PubMed
概括

维坦尼亚凝血菌茎提取物显示出显著的抗菌,抗糖尿病和抗氧化特性. 计算分析确定了具有多目标潜力的强效类化合物,验证了其传统医疗用途.

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Insensitive Nuclei Enhanced by Polarization Transfer (INEPT) is an advanced Nuclear Magnetic Resonance (NMR) technique specifically designed to detect and enhance the signals of low-abundance nuclei, such as carbon-13 and nitrogen-15, in small molecules. The fundamental principle behind INEPT is the transfer of polarization from a more abundant and highly polarizable nucleus, typically hydrogen-1, to the low-abundance nucleus of interest. This process effectively boosts the NMR signal of the...
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In pharmaceutical development, it's crucial to establish a predictive in vitro–in vivo correlation (IVIVC) for two or more formulations to gain a comprehensive understanding of release properties. IVIVC reduces the need for costly in vivo studies and facilitates the establishment of meaningful dissolution specifications with significant cost savings and decreased regulatory burden. Furthermore, a meaningful IVIVC should predict Cmax and AUC within 20%, aligning with FDA guidance while adhering...