在急性初级保健患者的急性初级保健入院期间进行协作药物评估:一个随机对照试验
Leonor Roa Santervas1,2,3, Eva Skovlund4, Espen Saxhaug Kristoffersen5,6
1Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Age and ageing
|February 20, 2026
概括
在老年人急性住院期间的药物评估没有改善与健康有关的生活质量. 这项研究建议在健康稳定期间,专注于以患者为中心的策略,以获得更好的结果.
科学领域:
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 老年人的多药性增加了不适当处方和不良药物事件的风险.
- 以前的研究表明,在住家的老年人中,药物评价改善了与健康相关的生活质量 (HRQoL).
- 在急性住院期间,这些审查的有效性仍然不确定.
研究的目的:
- 评估市政住院急性护理单位 (MIPAC) 住院患者协作药物评价的影响.
- 为了确定急性护理期间的药物评价是否可以改善老年人的HRQoL.
主要方法:
- 一个单盲,随机对照试验,涉及70岁或以上的患者,至少服用六种常规药物.
- 参与者被录取到MIPAC单位,并随机选择接受结构化药物审查或通常的护理.
- 主要结局是使用15D仪器在16周测量HRQoL,次要结局包括功能,口腔健康,医疗保健使用和死亡率.
主要成果:
- 16周后,干预组和对照组之间没有发现HRQoL (15D得分) 的显著差异.
- 虽然干预组在入院期间有更多的药物变化,但这些差异在出院后没有持续.
- 在两组之间的二次结果中没有发现显著差异.
结论:
- 在急性初级保健入院期间的协作药物评估没有提高老年人的HRQoL.
- 研究结果强调了在稳定的健康阶段实施纵向,以患者为中心的策略的重要性,而不是急性入院.
相关概念视频
01:15Drug Dosing: Geriatric Patients
308
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
308
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
257
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
257
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
249
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
249
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
748
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
748
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
274
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
274
01:28Drug Therapy
318
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
318