甲基相关的营养质量和中风:美国成年人中中风的流行率和特定死亡率
1Department of Neurosurgery, the First Hospital of China Medical University, Shenyang 110001, China.
概括
通过甲基相关营养素质量指数 (MNQI) 测量的一碳营养素的摄入量较高,与中风的发病率较低和中风特定死亡风险降低有关. 这表明营养充足是大脑血管健康的关键.
科学领域:
- 营养科学 营养科学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 单碳营养素对同型氨酸代谢和内皮功能至关重要,可能保护大脑血管系统.
- 甲基相关营养素质量指数 (MNQI) 量化了七种关键的单碳营养素的充分性.
- 在一般人群中,MNQI与中风结局之间的关联需要进一步研究.
研究的目的:
- 检查甲基相关营养素质量指数 (MNQI) 与先前中风的患病率之间的关系.
- 调查MNQI与中风特异性和全因死亡率的关联.
- 探索MNQI和中风结果的剂量反应关系和效果修改.
主要方法:
- 通过使用两个24小时的饮食回忆,对全国代表性的成年人群进行分析 (NHANES 2005-2014,n=22,374).
- 基于蛋白质,叶酸,胆, рибофлавин,维生素B6,B12和的摄入量充足性的MNQI (0-10) 的计算.
- 调整了多个共同变量的调查加权回归模型 (修改后的Poisson和Cox),与死亡结果与国家死亡指数联系在一起.
主要成果:
- 较高的MNQI (≥6比<6) 与以前中风的患病率显著降低 (PR 0.75).
- 每增加1点的MNQI与以前中风的患病率降低了6% (PR 0.94).
- 较高的MNQI与中风特异性死亡率 (HR 0.91每点) 相反相关,但与全因死亡率无关.
结论:
- 与甲基相关的营养素质量的提高独立地与先前中风的可能性降低和中风特定死亡风险降低有关.
- 单碳营养素的营养充足性是预防脑血管疾病的潜在可修改因素.
- 需要进一步的研究和临床试验,以改善叶酸,B族维生素和胆摄入量的质量.
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