长度核磁共振 (MRI) 基于内体积和头骨厚度的变化,在超染色白血病和多发性硬化症中观察到
Guus H J Vorst1, Nicole I Wolf1, David R van Nederpelt2
1Amsterdam Leukodystrophy Centre, Department of Child Neurology, Emma Children's Hospital, and Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam 1105 AZ, the Netherlands.
NeuroImage. Clinical
|February 20, 2026
概括
在甲色白血病 (MLD) 和多发性硬化症 (MS) 患者中,内体积 (ICV) 减少,骨厚度增加. 在神经成像研究中使用ICV作为正常化因素时,这些变化可能会影响缩估计.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 内体积 (ICV) 在成年人中通常被认为是稳定的,并用于神经成像中的正常化.
- 在白血病患者中观察到加厚的头骨表明了头骨形态的潜在变化.
研究的目的:
- 量化头骨厚度和ICV在患有甲色白血病 (MLD) 和患有多发性硬化症 (pwMS) 的患者.
- 与对照组相比,研究这些患者群体中ICV和头骨厚度之间的关系.
主要方法:
- 来自MLD,MS和对照组的横截面和纵向MRI扫描的回顾性分析.
- 使用自动细分技术来确定头骨厚度和ICV.
- 统计分析比较了ICV和头骨厚度随时间变化以及不同组之间的变化.
主要成果:
- 年轻的MLD参与者显示ICV的显著下降.
- 与对照组相比,MLD和pwMS组都表现出ICV损失和骨加厚.
- 在成年MLD和pwMS患者中观察到ICV和头骨厚度之间的负相关性,但在对照组中没有.
结论:
- 在MLD和MS中,ICV的减少和头骨的加厚发生,即使在年轻成年时也是如此.
- 这些体积变化可能导致低估大脑缩,当ICV被用作正常化因素.
- 需要进一步的研究来验证这些发现及其临床影响.
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