与肠道失生症相关的不孕症:益生菌和共生菌补充剂的有效性
Samaneh Abdolmohammadi-Vahid1, Vida Ebrahimi1, Mohammad Sadegh Soltani-Zangbar1
1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Journal of reproductive immunology
|February 20, 2026
概括
益生菌和协生菌通过改善肠道健康和代谢功能来改善不孕症的前景. 协生菌可能会带来更大的益处,但需要对怀孕结果进行更多研究.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
背景情况:
- 不孕症影响全球17%的夫妇,越来越多地与肠道疾病和免疫代谢失衡有关.
- 肠道微生物群在调节胰岛素敏感性和生殖激素方面发挥着至关重要的作用.
- 肠道细菌的不平衡与各种不孕不育因素有关,包括多囊性卵巢综合征 (PCOS).
研究的目的:
- 探索益生菌和共生菌在治疗不孕症中的作用.
- 为了比较益生菌与共生菌在改善不孕症相关参数方面的疗效.
- 评估基于微生物群的干预措施在不孕症治疗中的潜力.
主要方法:
- 审查当前关于益生菌 (乳酸菌,双菌) 和协生菌在不孕症中的研究.
- 对研究对肠道细菌,胰岛素敏感性,生殖激素和炎症的影响进行分析.
- 评估有关生殖结果的证据,如怀孕和活产率.
主要成果:
- 益生菌可以恢复肠道平衡,改善胰岛素敏感性,调节生殖激素.
- 协生菌增强微生物的多样性,短链脂肪酸的生产,以及免疫内分泌功能.
- 对不孕症的代谢,激素和炎症方面,共生菌可能比益生菌更有效,特别是在PCOS患者中.
结论:
- 益生菌和共生菌都有有利的安全概况,用于不孕症管理.
- 协生菌在改善与不孕症相关的关键参数方面显示出比益生菌更大的疗效潜力.
- 需要进一步的研究来证实对最终生殖结果的共生优势,支持个性化,基于微生物群的不孕症策略.
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