儿童暴露于多种持久性有机污染物和中年认知功能
Feitong Wu1, Noora Kartiosuo2, Jari Kaikkonen3
1Department of Cardiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
The Science of the total environment
|February 20, 2026
概括
儿童暴露于持久性有机污染物 (POPs) 与成人记忆力和学习能力的下降有关. 儿童时期高水平的特定POP如HCB,p,p-DDT和PCB99与晚年认知功能较差有关.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 早期暴露于持久性有机污染物 (POPs) 对成人认知功能的长期影响仍然在很大程度上未被研究.
- 这项研究调查了儿童血清POP水平与中年认知能力之间的关系.
研究的目的:
- 为了确定儿童暴露于持久性有机污染物 (POPs) 与成年期中期的认知功能有关.
- 确定有助于潜在认知缺陷的特定POPs.
主要方法:
- 一项前性队列研究,涉及1304名3-18岁儿童.
- 在儿童时期测量了18种血清POP,包括六二 (HCB),p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) 和多双 (PCB).
- 使用CANTAB计算机化测试电池评估成年期中期的认知功能,分析记忆,学习,工作记忆,反应时间和信息处理. 使用加权定量总和 (WQS) 回归来得出 POP 混合物指数.
主要成果:
- 增加POP混合物指数与中年人的记忆和学习能力下降有关 (β = -0.086,95% CI: -0.160至 -0.011).
- 这种认知衰退相当于大约1.7年的额外衰老.
- 该POP混合物主要由六二 (HCB),p,p'-二二三乙烯 (p,p'-DDT) 和多二99 (PCB99) 组成.
结论:
- 儿童暴露于多种POP的高水平,特别是HCB,p,p'-DDT和PCB99,与中年期的记忆和学习受损有关.
- 这种关联是独立于成年人接触POP的,这表明生命早期的脆弱性是一个关键的窗口.
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