系统性炎症和多环芳联合加速肺功能衰退:来自武汉-珠海队列的证据
Quanhong Liu1, Liangliang Ju1, Zhilin Zheng1
1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
系统性炎症显著降低肺功能,加速衰退. 与多环芳 (PAHs) 暴露相结合,它会使一般人群的呼吸系统障碍恶化.
科学领域:
- 环境健康 环境健康
- 肺部病理学 肺部病理学
- 生物标志物 生物标志物
背景情况:
- 系统性炎症与各种慢性疾病有关.
- 它对一般人群肺功能的影响和与PAH暴露的相互作用尚未研究.
研究的目的:
- 开发和验证一个全身炎症评分.
- 为了检查这一分数,PAH暴露和肺功能之间的关联.
- 调查对呼吸系统健康的综合影响.
主要方法:
- 使用WBC,hs-CRP,IL-6,IL-22和CC16开发了一个全身炎症得分.
- 分析了来自武汉-珠海队列 (n=5662) 的横截面和纵向数据.
- 评估的肺功能 (FEV1,FVC,PEF) 和尿路OH-PAHs.
主要成果:
- 每个炎症得分单位的下降与肺功能减弱有关 (FEV1,FVC,PEF).
- 高的炎症评分与加速的每年肺功能下降相关.
- 结合高炎症和PAH暴露,肺功能显著下降.
结论:
- 系统性炎症独立地损害肺功能,加速衰退.
- 暴露于PAH会加剧由炎症驱动的肺功能损失.
- 监测系统性炎症对于环境暴露环境中的呼吸系统健康至关重要.
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