从转移性差差分化的肉瘤引起的第三级心房静脉阻塞,暗示狗的骨髓肉瘤
K E Moy-Trigilio1, H R Coffin2, R P Taylor2
1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
概括
一种犬肉瘤导致了三度心房静脉阻塞,导致昏迷和厌食症. 尸体解剖揭示了多焦点瘤病变,其组织病理学优先考虑骨髓瘤.
科学领域:
- 兽医病理学 兽医病理学
- 狗类瘤学 狗类瘤学
- 心血管病理学心血管病理学
背景情况:
- 一只9岁的狗呈现出严重的嗜,厌食症和心.
- 临床症状表明心脏显著受到损害.
研究的目的:
- 在狗患者中调查第三级心房 (AV) 阻塞和相关临床症状的原因.
- 描述在诊断评估和尸体解剖期间发现的瘤病变的性质和程度.
主要方法:
- 诊断评估包括体检,诊断成像和临床病理评估.
- 尸体解剖和对受影响组织进行全面的本病理学检查.
- 根据形态特征对肉瘤亚型的优先考虑.
主要成果:
- 诊断出三级AV阻塞,归因于隔膜AV结合区域的透性质量.
- 多焦点瘤病变在心周,心肌,AV结节,肋骨,脏,胰腺和介质中得到证实.
- 组织病理学揭示了差差分化的肉瘤,具有暗示骨肉瘤的特征.
结论:
- 一种差异化瘤,可能是骨类瘤的起源,是导致狗心脏和全身疾病的主要原因.
- 肉瘤的多焦点传播导致了广泛的器官参与,并导致了致命的结局.
- 这一案例凸显了在对狗的AV阻塞进行差异诊断时考虑攻击性,转移性瘤的重要性.
相关概念视频
Dysrhythmias IV: Characteristics of Bradyarrhythmias
642
Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
642
Rous Sarcoma Virus (RSV) and Cancer
6.5K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
6.5K
Cardiomyopathy III: Hypertrophic Cardiomyopathy
550
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
550
Cardiomyopathy IV: Restrictive Cardiomyopathy
628
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
628


