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16小时的禁食优化了小鼠和人类的癌症免疫疗法

Sheng Chen¹, Tianyi Hu², Kaixiang Zhu³

¹Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310017, P.R. China; Cancer Center, Zhejiang University, Hangzhou 310058, P.R. China.

Cell metabolism

|February 20, 2026

概括

短暂的16小时禁食通过改变瘤代谢来增强癌症免疫疗法. 这种短期禁食可以促进CD8+T细胞的功能,改善小鼠和人类的抗瘤能力.

科学领域:

癌症研究癌症研究
免疫学免疫学免疫学
代谢调节代谢调节代谢调节

背景情况:

饮食干预措施在癌症治疗中表现有前途,但往往涉及到长期的,耐受性较差的治疗方案.
暂时的营养缺乏对瘤细胞和瘤微环境 (TME) 内的免疫细胞之间的代谢相互作用的影响尚不清楚.

研究的目的:

为了研究短暂的16小时禁食对免疫治疗疗效的影响.
阐明短期禁食增强TME内抗瘤免疫力的机制.

主要方法:

对接受免疫治疗的小鼠和人类患者进行了16小时的禁食治疗.
进行了代谢和免疫学分析,以评估TME的变化,包括营养偏好,异黄素水平和CD8+T细胞功能.

主要成果:

短期禁食增强了小鼠和人类的免疫疗法疗效.
禁食诱导了异黄素的内积累,该异黄素重新配置了CD8+T细胞表观遗传程序和脂重塑.
在患者中,短期禁食促进了CD8+ T细胞克隆扩张和细胞毒性程序.

结论:

简短的16小时禁食是临床上可行的,耐受性良好的饮食干预措施,可以增强免疫疗法.
禁食会在TME内抵制营养竞争,创造一个代谢窗口来增强抗瘤免疫反应.
这种饮食策略提供了一个可操作的方法来加强现有的免疫疗法方案.

关键词:

饮食干预的干预是饮食干预免疫检查点治疗疗法免疫检查点治疗免疫代谢的免疫代谢.瘤代谢瘤代谢瘤微环境是一个微环境.

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