含有不同活性剂的牙膏在治疗根的使用:通过网络元分析进行系统审查
Haoran Chen1, Yangyang Li2, Robert Hill1
1Institute of Dentistry, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.
Journal of dentistry
|February 20, 2026
概括
高度化牙膏是最有效的管理根 кариес,减少损伤深度,并改善硬度. 处方化物或无处方可用的含有氨酸或生物活性成分的选择为根管理提供了替代方案.
科学领域:
- 牙科 牙科是指牙科的专业.
- 皮肤病学 皮肤病学 皮肤病学
- 预防性牙科 预防性牙科
背景情况:
- 根是一种严重的口腔健康问题,特别是在老年人群和具有特定风险因素的个体中.
- 有效的管理策略对于预防牙脱落和保持口腔健康至关重要.
- 多种活性成分的牙膏配方广泛用于牙损伤的预防和治疗.
研究的目的:
- 系统地审查和评估牙膏的证据,其中包含用于治疗根的不同活性成分.
- 在实验室,现场和临床环境中比较各种牙膏配方的疗效.
- 为了确定最有效的成分和度用于根管理.
主要方法:
- 按照Cochrane指导方针进行系统审查,在9个数据库中进行文献搜索,截至2024年1月31日.
- 使用质量评估工具评估的体外和实地研究;使用Cochrane偏差风险工具 (RoB2.0) 评估的临床研究 (RoB2.0).
- 进行元分析以计算各种结果的平均差异和风险比率,并使用GRADE评估证据确定性.
主要成果:
- 分析显示,与安慰剂相比,牙膏显著减少了根病变深度和矿物质损失.
- 临床研究表明,高度化 (5,000 ppm) 或1.5%的氨酸加上1,450 ppm的单酸牙膏在硬化和扭转病变方面是有效的.
- 与标准牙膏相比,含有化,硫酸和二酸的生物活性牙膏显示病变硬度增加.
结论:
- 高度化牙膏是最有效的非侵入性疗法,可以阻止活跃的根,减少病变深度和改善硬度.
- 生物活性牙膏和化物与氨酸为无法使用高化物处方的患者提供潜在的治疗选择.
- 含有1,450 ppm化的标准牙膏对于患有活跃根的高风险患者可能不足.
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