在膝关节骨关节炎患者中,疼痛敏感化与前额叶皮层激活和单任务和双任务行走期间的运动模式的关联
Soyoung Lee1, Ehyun Kim1, Tuhina Neogi2
1Department of Physical Therapy, Sargent College of Health & Rehabilitation Sciences, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA.
The journal of pain
|February 20, 2026
概括
膝关节OA中中央疼痛敏感性与前额叶皮质活动增加和走路时的步态变化有关. 准中央敏感化可以改善膝关节骨关节炎患者的执行控制和行走.
科学领域:
- 神经科学是一个神经科学.
- 整形外科 整形外科 整形外科
- 康复科学 康复科学 康复科学
背景情况:
- 膝关节骨关节炎 (OA) 可以导致疼痛敏感,可能会增加前额叶皮层 (PFC) 在行走期间的活动.
- 认知需求可能会加剧患有膝盖OA的个体的PFC激活.
研究的目的:
- 调查中央和外围疼痛敏感化和行走期间PFC激活之间的关联.
- 检查膝关节OA中单一和双重任务条件下的疼痛敏感度,PFC活动和行走性能之间的关系.
主要方法:
- 48名患有症状膝关节骨质炎的个体接受了单任务行走 (STW) 和双任务行走 (DTW) 的认知任务.
- 通过在手腕和膝盖的压力疼痛值 (PPT) 来测量中心和外周敏感度.
- 前额叶皮层 (PFC) 氧化血红蛋白 (HbO2) 使用功能近红外光谱学 (fNIRS) 记录.
主要成果:
- 在DTW期间,更高的中央敏感度 (下手腕PPT) 与左背侧PFC激活的增加以及更大的步伐长度变化有关.
- 较高的外周敏感性 (下膝 PPT) 与改变的步行速度有关.
- 最集中敏感的组在行走任务中显示出中度较高的PFC激活.
结论:
- 膝关节OA中中央疼痛敏感性与更大的PFC参与和不太稳定的步态有关.
- 针对中央敏感化可能是一个可行的治疗策略,以减少认知负载,并提高膝关节OA患者的步态.
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