在肺癌中吸烟依赖的循环非编码生物标志物
1Department of Medical Laboratory Technology, Faculty of Nursing and Health Sciences, Jazan University, Jazan 45142, Saudi Arabia; Health Research Centre, Jazan University, Jazan, Saudi Arabia.
Clinica chimica acta; international journal of clinical chemistry
|February 20, 2026
概括
吸烟会影响肺癌的进展和循环中的核酸. 本综述探讨了吸烟依赖如何影响循环非编码RNAs (ncRNAs),以便在肺癌检测和监测中更好地解释液体活检.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物 生物标志物
背景情况:
- 吸烟是肺癌的主要原因,影响瘤发育和循环中的核酸.
- 在吸烟者中解读液体活检信号需要专门的方法,因为核酸概况发生了改变.
- 循环非编码RNAs (ncRNAs) 显示为肺癌检测,预后和治疗监测的生物标志物.
研究的目的:
- 审查和整合肺癌亚型中吸烟依赖模式的证据.
- 为了将吸烟暴露和并发性疾病与循环RNA配置文件相关联,以获得生物标志物的信息性.
- 检查无细胞与细胞外囊 (EV) 相关的ncRNAs的实验室实施和分析/临床权衡.
主要方法:
- 在PubMed和Scopus数据库 (2010-2025) 中进行全面的文献搜索.
- 现有证据与当前审查结果的整合.
- 吸烟暴露量和并发症与循环RNA资料的相关性.
- 讨论实验室预分析,规范化,平台选择和风险评分报告.
主要成果:
- 循环的ncRNAs (miRNAs, lncRNAs) 与肺癌的早期检测,组织学差异化,生存结果和治疗反应有关.
- 吸烟依赖会影响循环的RNA配置文件,影响生物标志物的效用.
- 无细胞和EV相关的ncRNA具有不同的分析和临床特征,EV具有潜在的增量价值.
结论:
- 了解吸烟对循环RNA特征的影响对于在肺癌中有效的液体活检解释至关重要.
- 标准化实验室实践和多中心验证对于ncRNA生物标志物的临床应用至关重要.
- ncRNA具有各种临床应用的潜力,包括不确定的结节选和治疗监测.
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