癌症治疗相关心血管毒性的生物标志物
Jiaxin Song1, Shuqin Liu1, Xiaohui Shi1
1Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong) and School of Life Science, Shanghai University, Nantong, P.R. China; Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Science, Shanghai University, Shanghai, P.R. China.
癌症治疗引起的心血管毒性 (CTR-CVT) 是一个重大挑战. 像microRNAs和proteomic标记物这样的新生物标记物可以改善CTR-CVT的早期检测,从而提高癌症治疗结果.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 癌症治疗引起的心血管毒性 (CTR-CVT) 是一个重大的临床挑战.
- 机制包括氧化应激,炎症和直接的心肌细胞损伤,这些病因来自于像 antracyclines 和 trastuzumab 这样的疗法.
- 传统的生物标志物 (热素,尿酸) 表明急性损伤,但缺乏对早期CTR-CVT的敏感性.
研究的目的:
- 审查用于检测癌症治疗诱导的心血管毒性的传统和新型生物标志物.
- 突出生物标志物查高通量技术的进步.
- 强调综合生物标志物方法对于早期CTR-CVT检测的重要性.
主要方法:
- 对CTR-CVT分子机制和生物标志物的文献综述.
- 讨论传统的生物标志物 (心脏特罗波宁,尿素).
- 探索新兴的生物标记物 (miRNAs,蛋白质组标记物) 和高通量技术 (aptamers,近距离延伸试验).
主要成果:
- 新型生物标记物,如特定的microRNAs (miR-29,miR-223-3p) 和蛋白质标记物 (细胞因子,免疫球蛋白) 在检测亚临床心脏损伤方面表现有前途.
- 高通量技术提高了CTR-CVT生物标志物的特异性和灵敏性.
- 多种生物标志物的整合为CTR-CVT监测提供了一个全面的方法.
结论:
- 早期发现CTR-CVT对于治疗癌症患者至关重要.
- 新兴生物标志物和先进技术显著提高了识别和监测CTR-CVT的能力.
- 一个全面的生物标志物策略可以在癌症治疗期间优化患者的治疗结果.
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