战争和复杂紧急情况中的耐药结核病:危及消除结核病和控制抗菌素耐药性的进展 - - 范围审查和前景
Ignacio Monedero-Recuero1,2, Xiaolin Wei3, Fabienne Jouberton4
1Damien Foundation, Brussels, Belgium ignacio.monederorecuero@actiondamien.be.
BMJ global health
|February 20, 2026
概括
在复杂的紧急情况 (CE) 中,对耐药结核病 (DR-TB) 的管理是具有挑战性的,因为冲突,访问和数据有限,特别是对弱势群体来说. 创新是有希望的,但扩大支持和研究对于消除结核病至关重要.
科学领域:
- 全球卫生安全全球卫生安全
- 传染病流行病学 传染病流行病学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 复杂的紧急情况 (CE) 和长期的冲突严重破坏了卫生系统,阻碍了结核病 (TB) 护理.
- 在受冲突影响的环境中,对抗药性结核病 (DR-TB) 的管理尤其具有挑战性,目前证据有限.
- 战争和战后条件可能会扩大结核病耐药性,加剧全球抗菌素耐药性危机.
研究的目的:
- 分析在欧洲的环境中提供DR-TB护理的全球经验和挑战.
- 在人道主义危机期间识别DR-TB管理中的风险因素,当前做法和研究缺口.
主要方法:
- 对同行评审文章和灰色文献进行全面的范围审查.
- 与参与CEDR-TB护理的执行机构进行商.
主要成果:
- 诊断机会有限和通报率低 (<20%) 标志着欧洲的DR-TB治疗.
- 确诊患者的治疗成功率与全球平均水平相当,创新改善了治疗结果.
- 关于弱势群体 (流离失所者,囚犯,儿童) 的数据很少,阻碍了有针对性的干预.
结论:
- 冲突显著改变了DR-TB的动态,威胁到结核病消除目标和全球抗菌素耐药性的努力.
- 创新提高了欧洲的DR-TB护理可行性,但获得仍然是一个主要的限制.
- 迫切需要扩大结核病支持和有针对性的研究,特别是对欧洲的弱势群体.
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