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Updated: May 12, 2026

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用于细菌与宿主相互作用研究的人类呼吸道器官:方法,见解和转化承诺

Yanhong Huang1, Shumin Liao1, Damien Chua2

  • 1Department of Pharmacology, Southern University of Science and Technology, Shenzhen, Guangdong, China.

Thorax
|February 20, 2026
PubMed
概括

人类呼吸道有机体 (HAO) 为研究细菌呼吸道感染提供了一个相关的模型,促进我们对病变发生的理解,并改进对抗抗菌素耐药性的治疗策略.

关键词:
气道上皮质 气道上皮质细菌感染 细菌感染呼吸道感染 呼吸道感染

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Microbiota of the Respiratory Tract01:29

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The human respiratory tract, comprising the upper and lower segments, serves as a critical interface with the external environment. The upper respiratory tract (URT)—including the nostrils, sinuses, pharynx, and oropharynx—is heavily colonized by microbes, while the lower respiratory tract (LRT), composed of the larynx, trachea, bronchi, and lungs, was long thought to be sterile. However, recent molecular studies have revealed that the lungs are not devoid of microbes but act more like...