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切除HAS/GAED患者的临床病理特征和预后:来自中国的多中心嵌套病例对照研究

Lihu Gu¹, Xiaoming Zhang², Shengqiang Ji³

¹Department of General Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

|February 20, 2026

概括

胃肝腺癌 (HAS) 和胃腺癌与肠芽细胞分化 (GAED) 是具有不良结果的侵袭性胃癌. 这些亚型表现出明显的特征,与传统的胃癌相比,它们的生存率更差.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

胃肝腺癌 (HAS) 和胃腺癌与肠芽细胞分化 (GAED) 是罕见的,侵袭性胃癌 (GC) 亚型.
这些亚型具有独特的临床病理学挑战和预后.

研究的目的:

调查HAS和GAED的临床病理学特征.
为了比较HAS/GAED患者与传统GC (cGC) 患者的预后结果.

主要方法:

一项多中心的回顾性研究,涉及107名HAS/GAED患者和428名cGC患者.
倾向性得分匹配 (PSM) 用于队列比较.
使用考克斯模型和卡普兰-梅尔曲线分析了无疾病生存率 (DFS),胃癌特异性生存率 (GCSS) 和整体生存率 (OS).

主要成果:

与cGC相比,HAS/GAED组的瘤大小更大,差异化较差,CEA更高,HER2过度表达.
升高的CEA,PNI和PN类别是独立的危险因素;术后化疗具有保护作用.
与cGC患者相比,HAS/GAED患者的DFS,GCSS和OS明显较差.

结论:

HAS和GAED是高度侵略性的GC亚型,具有明显的特征和不良预后.
在HAS和GAED之间没有发现显著的生存差异.
了解这些攻击性亚型对于改善患者的治疗结果至关重要.

关键词:

临床病理学特征临床病理学特征胃腺癌与肠芽细胞分化的胃腺癌.胃的肝腺癌胃的肝腺癌预测预后预后

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