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Updated: Feb 22, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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监管和药物发现机会的CDK结构机制的多样性

Rhianna J Rowland1, Martin E M Noble1, Jane A Endicott1

  • 1Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

Trends in biochemical sciences
|February 20, 2026
PubMed
概括

循环素依赖激酶 (CDK) 调节细胞循环和基因转录. 最近的结构研究揭示了对CDK调节的新见解,为开发更有选择性的癌症疗法提供了潜力.

关键词:
在CDK CDK中.在X射线晶体学.低温电子显微镜的低温电子显微镜骑行者是骑自行车的人.一个简短的线性图案.基于结构的药物设计.

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