看不见但有影响力:痛风是心血管保健中被忽视的并发症
Zaayneb Sediqi1, Oliver Buchhave Pedersen2, Søren Jepsen3
1Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Clinical therapeutics
|February 20, 2026
概括
在心血管疾病 (CVD) 患者中,痛风的治疗往往是不充分的,可能会增加心血管事件的风险. 优化尿酸降低疗法对于这种高风险人群的更好的结果至关重要.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 痛风影响了3%的人口,许多人没有得到足够的治疗.
- 痛风在心血管疾病患者中很常见,需要有效的管理来预防并发症.
研究的目的:
- 评估心血管疾病 (CVD) 患者遵守推的痛风治疗.
- 评估在患有心血管疾病的痛风患者中达到目标血清尿酸盐水平的程度.
主要方法:
- 对有确认尿酸水晶的痛风患者进行前性队列研究.
- 纳入标准:并发性心血管疾病 (缺血性心脏病,心房动或心力衰竭).
- 主要结局:在诊断后2年达到目标血清尿酸盐水平 (托菲<0.36 mmol/L或<0.30 mmol/L).
主要成果:
- 在286名痛风患者中,有41%患有心血管疾病;年龄中位数为71,男性为76%.
- 59%的人达到建议的酸盐水平;只有33%的托菲患者达到溶解酸盐的水平.
- 处方Allopurinol剂量往往不足 (平均253毫克/天) 来达到酸盐的目标水平.
结论:
- 在心血管疾病患者中,痛风的治疗往往是不充分的,可能会增加心血管事件的风险.
- 优化Allopurinol剂量和遵守指南可能会改善痛风和心血管疾病的结果.
- 痛风是心血管疾病中显著的并发症,需要在心血管保健中进行综合管理.
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