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Updated: Feb 22, 2026

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
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Published on: November 22, 2019

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EZH2和DNA甲基化之间的交叉声调解神经内分泌前列腺癌血统可塑性

Richa Singh1, Varadha Balaji Venkadakrishnan2,3,4, Eddie Imada1

  • 1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

Nature communications
|February 20, 2026
PubMed
概括

通过DNA甲基化和增强性凝血同源2 (EZH2) 的增强剂,可以在表观遗传上控制前列腺癌谱系的可塑性. 它们的相互作用决定了神经内分泌前列腺癌 (NEPC) 基因表达,揭示了新的治疗点.

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