高蛋白质肠道营养在重症监护病房的患者进行先进的早期动员:随机对照试验的协议
Ginga Suzuki1, Yuji Iwanami2, Masayoshi Nakazawa2
1Critical Care Center, Toho University Omori Medical Center, 6-11-1, Omori Nish, Ota-ku, Tokyo, Japan. ginga.suzuki@med.toho-u.ac.jp.
Trials
|February 20, 2026
概括
这项研究调查了高蛋白营养与早期动员相结合是否能改善重症监护室 (ICU) 患者的康复. 这些发现旨在增强身体功能,减少严重疾病后的康复时间.
科学领域:
- 临界护理医学 临界护理医学
- 营养科学 营养科学
- 康复医学 康复医学 康复医学
背景情况:
- 早期营养治疗和动员是重症病患在重症监护室 (ICU) 的关键干预措施.
- 这些干预措施的独立应用并没有持续改善临床结果.
- 结合高蛋白营养与早期动员的协同效应仍然未被探索.
研究的目的:
- 研究将高蛋白营养与重症患者早期动员相结合的潜在协同效应.
- 为了确定这种综合方法是否能在ICU退院后促进更好的身体和功能恢复.
- 提供关于高蛋白营养在密集康复期间的作用的强有力的证据.
主要方法:
- 一个单中心,前性,参与者和评估者盲目的随机对照试验,涉及92名机械通风成人ICU患者.
- 随机分配到通常的蛋白质 (1.2 g/kg/day) 或高蛋白质 (1.8 g/kg/day) 组.
- 在两组中使用移动患者升降器的标准化早期动员协议,功能独立度量 (FIM) 运动得分作为医院出院的主要结果.
主要成果:
- 主要结果:在医院出院时,功能独立度量 (FIM) 的运动分数.
- 二次结果:认知FIM得分,简要疼痛清单得分,ICU和住院时间长度,以及出院的意愿.
- 数据收集和分析将为联合干预的有效性提供见解.
结论:
- 这项试验是首次评估高蛋白营养和ICU患者标准化的高强度早期动员的协同效应.
- 该研究侧重于蛋白质剂量作为唯一的干预变量,以确保统一的动员强度.
- 预计这些发现将为未来的多中心试验提供信息,并指导改善ICU后功能恢复的策略.
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