炎症性肠道疾病患者的E型肝炎感染:系统性审查和元分析
Dionysios Kogias1, Georgios Kouklakis1, Vasileios Papadopoulos2
1First Department of Internal Medicine, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
Journal of viral hepatitis
|February 20, 2026
概括
肝炎E病毒 (HEV) 感染在炎症性肠病 (IBD) 患者中很常见,类似于一般人群. 然而,严重的免疫抑制可能会增加风险,需要在IBD患者肝酶升高的情况下进行HEV测试.
科学领域:
- 胃肠病学 胃肠病学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 机会性感染在炎症性肠病 (IBD) 中越来越令人担忧,特别是在免疫抑制疗法中.
- 肝炎E病毒 (HEV) 是全球病毒性肝炎的重要原因,但其在IBD中的作用尚不清楚.
研究的目的:
- 系统地审查和元分析HEV感染和IBD之间的关联.
- 确定IBD患者中HEV感染标志物的患病率,并将其与一般人群进行比较.
主要方法:
- 在PubMed/MEDLINE和Google Scholar进行了全面的文献搜索,截至2025年5月.
- 包括6项与1316名IBD患者的研究,评估HEV感染标志物 (抗HEVIgG,IgM,HEV-RNA).
- 研究质量是使用Joanna Briggs研究所分析跨部分研究的检查清单来评估的.
主要成果:
- 在IBD患者中,抗HEV IgG的综合流行率为13.5% (异质).
- 抗HEV IgM和HEV-RNA阳性率较低 (分别为1.9%和0.03%).
- 在IBD患者中,HEV的患病率与一般人群相似,但在免疫功能低下的移植接受者和强化免疫抑制患者中更高.
结论:
- 在IBD患者中,HEV的患病率通常反映出一般人群的情况.
- 在IBD患者中不明原因的肝酶升高需要考虑HEV感染.
- 在IBD中严重的免疫抑制可能会增加对持续的HEV感染和并发症的易感性,建议进行常规检测.
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