作为疼痛非四肢静脉形的生物标志物D-Dimer:对68名手术患者的回顾性分析
Makoto Shiraishi1, Kou Fujisawa1, Yuta Moriwaki1
1Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
The Journal of dermatology
|February 21, 2026
概括
静脉形的疼痛因位置而异. 升高的D-二聚物水平表明非四肢病变中的局部静脉凝血病,这表明疼痛管理的生物标志物.
科学领域:
- 血管外科 血管外科
- 血液学 血液学 血液学
- 疼痛医学 医学 疼痛医学
背景情况:
- 静脉形 (VMs) 是一种常见的先天性血管异常.
- 疼痛是超过50%的VM患者的重要症状,但其病理生理学尚不清楚.
- 在VM中观察到局部的血管内凝血病 (LIC),42-58%的患者的D-二次体水平升高.
研究的目的:
- 调查静脉形患者疼痛和凝血参数之间的关系.
- 探索基于静脉形的解剖位置的疼痛机制的潜在差异.
主要方法:
- 对68名接受手术切除VMs的患者进行了回顾性队列研究.
- 收集的人口统计数据和手术前凝血参数 (原血红素时间,aPTT,D-二次数,纤维素).
- 分析了疼痛的患病率及其与位置和凝血标志物的相关性.
主要成果:
- 55.9%的患者报告疼痛,在四肢VM (76.5%) 和非四肢VM (35.3%) 中明显高.
- 在非四肢VM中,高的D-二次体水平与疼痛相关 (3.25μg/mL对比0.63μg/mL,p=0.046).
- 在四肢VM或其他凝血参数中,没有发现疼痛和D-二次体之间的相关性.
结论:
- 静脉形的疼痛机制因解剖位置而异.
- 在非肢体VM中,LIC可能会导致疼痛,而在肢体VM中,机械因素可能会占主导地位.
- 手术前的D-二聚合物水平可以作为症状非肢体VMs的生物标志物.
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