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Updated: Feb 22, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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口服生物可用的环素A/B RxL抑制剂:优化一种新型宏环类的优化,针对E2F高和G1-S检查点受损的癌症

Justin A Shapiro1, Nathan J Dupper1, Breena Fraga-Walton1

  • 1Circle Pharma, 169 Harbor Way, South San Francisco, California 94080, United States.

Journal of medicinal chemistry
|February 21, 2026
PubMed
概括

研究人员开发了口服可用的宏环,针对Cyclin A/B治疗小细胞肺癌 (SCLC). 这些化合物有选择性地杀死癌细胞,并在临床前模型中显示瘤回归,目前在第一阶段临床试验中有一种主要候选物.

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Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry11:23

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