启发性肌肉训练对阻塞性睡眠呼吸暂停的影响:系统性审查和元分析
Chengcheng Zuo1,2, Jie Qin1, Zhe Wang1
1Department of Otolaryngology, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
Annals of the American Thoracic Society
|February 21, 2026
概括
启发性肌肉训练 (IMT) 改善了阻塞性睡眠呼吸暂停 (OSA) 患者的睡眠质量和心血管健康. 虽然它增强了呼吸能力,但IMT并没有显著降低呼吸暂停-呼吸暂停指数 (AHI),这表明它是一种辅助疗法.
科学领域:
- 肺部医学 肺部医学
- 睡眠医学 睡眠医学
- 心血管医学 心血管医学
背景情况:
- 启发性肌肉训练 (IMT) 正在探索阻塞性睡眠呼吸暂停 (OSA),以改善呼吸强度和症状.
- IMT对OSA患者关键临床结果的影响仍然不确定.
研究的目的:
- 系统地评估IMT对OSA严重程度,睡眠质量,呼吸功能和心血管标志物的影响.
- 综合来自成年OSA患者IMT干预的随机对照试验 (RCT) 的证据.
主要方法:
- 在PubMed,EMBASE,CENTRAL和Web of Science进行了系统的文献搜索.
- 包括RCT与IMT与控制/安慰剂进行了比较,分析了像AHI,PSQI,ESS,MIP,LSaO2,BP和BMI这样的结果.
主要成果:
- IMT在BMI,睡眠质量 (PSQI),最低氧和 (LSaO2),白天嗜睡 (ESS) 和最大吸气压 (MIP) 中显著改善.
- 益处还包括增强强迫生命能力 (FVC%) 和降低缩血压 (SBP).
- 在呼吸暂停-呼吸暂停指数 (AHI) 中没有明显的改善,由于干预方案和基线严重性而注意到异质性.
结论:
- 通过改善呼吸强度,睡眠质量和心血管健康,IMT为OSA患者提供临床上有意义的症状益处.
- IMT可以作为OSA症状管理的辅助疗法,而不是减少事件频率的主要治疗方法.
- 进一步的研究可能会澄清IMT在解决OSA的主要病理生理机制方面的作用.
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