从动物到芯片:炎症性肠病的临床前模型,重点是宿主微生物群相互作用
Satish Kumar1, Biswatrish Sarkar1
1Group Polyphenol-BIT, Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand 835215, India.
American journal of physiology. Gastrointestinal and liver physiology
|February 21, 2026
概括
炎症性肠病 (IBD) 研究越来越多地使用先进的人类衍生模型,超越动物研究. 这些新平台更好地代表了免疫微生物群相互作用,以改善IBD治疗翻译.
科学领域:
- 胃肠道学和免疫学
- 翻译医学是一种翻译医学.
- 微生物组研究 微生物组研究
背景情况:
- 炎症性肠病 (IBD),包括克罗恩氏病和性结肠炎,是一种慢性疾病,全球流行率不断上升.
- 传统的临床前IBD研究在很大程度上依赖于动物模型来研究疾病机制和试验疗法.
- 肠道微生物群失调被认为是IBD发病,进展和治疗反应的关键因素.
研究的目的:
- 批判性地评估现有的体内炎症性肠病 (IBD) 动物模型.
- 评估当前模型在IBD中代表免疫-微生物组-上皮相互作用的能力.
- 讨论新兴的人类衍生的体外平台作为IBD研究的补充翻译工具.
主要方法:
- 在炎症性肠病 (IBD) 研究中使用现有的体内动物模型的审查.
- 评估这些模型重复IBD关键特征的能力,包括免疫微生物群相互作用.
- 讨论新型的人类衍生体体内系统,如有机体和gut-on-chip技术.
主要成果:
- 动物模型在IBD研究中发挥了重要作用,但存在物种间的差异和有限的翻译可预测性.
- 现有的模型往往无法完全代表复杂的肠道微生物组和宿主免疫相互作用,这对IBD至关重要.
- 新兴的人类衍生的体外平台为研究IBD提供了更多与人类相关的模型.
结论:
- 先进的体外模型,包括器官和肠上芯片系统,对于弥合IBD临床前发现和临床应用之间的差距至关重要.
- 整合微生物组响应和免疫能力的体外模型是未来IBD研究的一个有希望的策略.
- 通过与人类相关的平台减少对动物模型的依赖与监管趋势保持一致,并增强IBD的翻译成功.
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