与年龄相关的黄斑退化中的地理缩:用于临床试验考虑的表型表征
Grace A Borchert1,2, Peter Charbel Issa3, Kanmin Xue1,2,4
1Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
概括
地理缩 (GA) 是一种与年龄相关的黄斑变性 (AMD) 的高级形式,导致视力丧失. 多式成像增强GA评估,帮助预后,临床试验选择和监测这种情况.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 视网膜疾病 视网膜疾病
背景情况:
- 地理缩 (GA) 是与年龄相关的黄斑变性 (AMD) 的晚期阶段,导致显著的中央视力丧失.
- 准确的GA表征对于预测疾病进展,指导患者管理和为临床试验选择参与者至关重要.
- 区分GA亚型,如帕奇科罗伊德GA,由于遗传学,表型和治疗反应的潜在差异,因此很重要.
研究的目的:
- 审查多式成像在地理缩 (GA) 的表型特征和评估中的作用.
- 要强调先进的成像技术如何提高对GA进展和患者分层治疗和临床试验的理解.
- 讨论新兴成像技术和人工智能在GA管理中的潜力.
主要方法:
- 审查目前和新兴的多式联络成像技术用于GA评估.
- 讨论不同的模式 (例如,OCT, fundus自光,近红外反射) 如何为GA的表征作出贡献.
- 在GA检测和监控中探索人工智能应用.
主要成果:
- 多式成像为GA提供了详细的表型特征,包括病变边界,范围和骨干涉.
- 光学连贯断层扫描 (OCT) 有助于区分GA亚型和评估与视觉功能相关的外视网膜缩 (iRORA/cRORA).
- 新兴技术和人工智能显示出更准确,可复制和自动化的GA评估和进展监测的前景.
结论:
- 多模式成像对于精确的GA分类,预后和患者选择新兴疗法和临床试验至关重要.
- 先进的成像技术,包括人工智能,对于监测GA的疾病进展和治疗反应至关重要.
- 在GA管理中更好地理解和应用成像技术可以为这种视力丧失的原因带来更好的患者咨询和治疗结果.
更多相关视频
相关概念视频
01:14Changes in Skin Color: Clinical Perspectives
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...