通过辅助生殖怀孕的夫妇在男性中患非生殖性癌症的风险:一项瑞典国家基登记册研究
Peter Zarén1,2, Michael Kitlinski1,3, Aleksander Giwercman1,2
1Department of Translational Medicine, Lund University, Malmö, Sweden.
European journal of epidemiology
|February 21, 2026
概括
接受辅助生殖,特别是细胞内精子注射 (ICSI) 的男性面临更高的非生殖性癌症风险,如结肠直肠癌和甲状腺癌. 这凸显了男性生育能力受损的扩大健康监测的必要性.
科学领域:
- 生殖医学 生殖医学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 在男性不孕症和生殖系统癌症 (丸,前列腺) 之间确立了联系.
- 关于男性生育能力受损非生殖性癌症风险的有限且相互矛盾的数据.
- 需要对不孕男性的生殖器官以外的癌症风险进行调查.
研究的目的:
- 为了比较通过辅助生殖与自然受孕怀孕的男性的非生殖癌症风险.
- 为了确定与男性生育能力障碍相关的特定非生殖癌症.
主要方法:
- 在瑞典 (1994-2014) 进行基于国家登记的队列研究.
- 包括1,137,829名第一次父亲.
- 使用了瑞典多代人登记,医疗出生登记,Q-IVF登记和癌症登记.
- 通过细胞内质精子注射 (ICSI) 或捐赠的精子来定义受孕时男性生育能力受损.
- 癌症诊断,死亡或研究结束的随访 (2014年12月31日).
主要成果:
- 通过ICSI (14,540) 或捐赠精子受孕的男性患非生殖性癌症的风险增加 (aHR 1.3).
- 结肠癌 (aHR 1.7),直肠癌 (aHR 1.8) 和甲状腺癌 (aHR 3.3) 的风险增加.
- 患有最严重生育问题 (ICSI/捐赠精子) 的男性患结肠直肠癌和甲状腺癌的风险更高.
结论:
- 男性生育能力受损,特别是需要ICSI或捐赠精子时,与非生殖性癌症的风险增加有关.
- 结肠直肠和甲状腺癌在患有严重生育障碍的男性中尤为频繁.
- 建议在接受生育治疗的男性进行扩大健康检查和长期随访.
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