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绘制食道癌免疫疗法的研究趋势:十年的主题演变和新兴优先事项
Huijun Jia1, Yifan Gong2, Chengguang Zhao3
1Cardiothoracic Department, Suqian First Hospital, Suqian, Jiangsu, China.
本文献分析揭示了食道癌免疫治疗研究的激增,特别关注PD-1/PD-L1抑制剂和组合疗法. 中国在全球贡献方面处于领先地位,研究正在向瘤微环境和抵抗机制发展.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 图书统计学 图书统计学
背景情况:
- 免疫疗法是食道癌的关键治疗方法,改善了生存率和个性化护理.
- 在生物标志物识别,组合疗法优化和管理副作用方面仍然存在挑战.
研究的目的:
- 从2015年到2024年进行食道癌免疫疗法研究的文献分析.
- 确定关键的研究趋势,有影响力的贡献者和不断变化的重点领域.
主要方法:
- 从科学网络核心收藏中对545篇出版物的图书统计分析.
- 使用关键词的同时出现和共同引用分析.
主要成果:
- 出版量从2019年大幅增加,在2021-2023年期间达到顶峰.
- 中国是主要贡献者 (67.7%),州大学是顶级机构.
- 研究热点包括PD-1/PD-L1抑制剂,组合疗法和瘤微环境.
- 研究重点从具体目标转移到机械研究 (TME,耐药性,预后).
结论:
- 食道癌免疫疗法研究正在迅速扩大,焦点有了显著的转变.
- 中国的重大贡献凸显了它在这个领域的核心作用.
- 未来的研究应该探索机械洞察力和临床应用,以改善患者的治疗结果.
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