高脂肪饮食和肥胖每一个增加瘤细胞的增殖和肌肉消耗在实验癌症中
Brittany R Counts1,2, Andrea Bonetto3,4,5,6,7, Ho Lam Chan3
1Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA.
American journal of physiology. Cell physiology
|February 21, 2026
概括
高脂肪饮食 (HFD) 和肥胖会通过增加炎症和肌肉损失,加剧癌症缓解症和瘤生长. 这些由饮食和脂肪驱动的因素,为癌症治疗提供了潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 代谢过程中的代谢.
- 免疫学 免疫学 免疫学
背景情况:
- 高脂肪饮食 (HFD) 和肥胖与癌症的发展和死亡率有关.
- 肥胖矛盾地与肺癌患者的更长生存时间相关,这表明身体质量的保护作用.
- 卡切西亚的特点是体重减轻和肌肉消耗,在肺癌中很常见,并且可能因肥胖而恶化.
研究的目的:
- 调查HFD和肥胖对癌症缓解症和瘤生长的独特和综合影响.
- 在使用HFD诱导的肥胖症和易斯肺癌 (LLC) 的小鼠中模拟癌症缓解症.
- 确定潜在的治疗点,以减轻缓解和瘤进展.
主要方法:
- 利用瘦身和HFD诱导的肥胖小鼠,有或没有LLC瘤.
- 评估体重,组织质量 (肌肉,脂肪,心脏),瘤负担和炎症标志物.
- 在组织中分析了细胞因子表达 (例如IL-6) 和STAT3酸化.
- 在体内和体外评估瘤细胞的增殖.
主要成果:
- 仅HFD就会加剧肌肉损失和炎症,但不会增加瘤负担.
- 患有瘤的肥胖小鼠表现出最严重的缓冲症,增加了瘤负担,增强了瘤细胞的增殖.
- 无论是HFD还是先前存在的肥胖症,都独立地放大了炎症,缓冲症和瘤生长.
- 来自肥胖HFD小鼠的血清在体外促进了LLC细胞的增殖.
结论:
- 高血压和慢性肥胖明显加剧与癌症相关的炎症和缓解症.
- 肥胖会显著恶化缓存症,促进瘤生长和扩散.
- 针对HFD诱导的炎症和肥胖驱动的缓解症可能提供治疗策略来减缓癌症的进展.
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