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Updated: Feb 23, 2026

Investigation of Beige Fat Biology and Metabolism Using the CRISPR SunTag-p65-HSF1 Activation System
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MRAP2通过保留的机制强化了GPCR信号,这些机制被肥胖相关的遗传变异破坏了

Aqfan Jamaluddin1, Rachael A Wyatt1, Johannes Broichhagen2

  • 1Department of Metabolism and Systems Science, University of Birmingham, Birmingham, UK; Centre of Membrane Proteins and Receptors (COMPARE), Universities of Birmingham and Nottingham, Birmingham, UK.

Cell reports
|February 21, 2026
PubMed
概括

梅拉诺科丁-2受体辅助蛋白2 (MRAP2) 通过与MC4R,MC3R和GHSR形成1:1复合体来调节食欲,促进信号传递和延迟受体内化.

关键词:
CP:代谢过程中的代谢.科普:分子生物学在G蛋白信号传递方面.辅助蛋白质是辅助的蛋白质.格林林受体的受体是什么 格林受体黑色皮质素受体的受体这是一种β-arrestin.

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