细胞内细菌调节口腔状细胞癌的免疫微环境
Yansu Wang1, Qiang Lin2, Zhongzheng Xiang3
1Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, China; Institute of Digital Health, Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, No. 1, Chengdian Road, Kecheng Zone, Quzhou 324003, China.
Cell reports
|February 21, 2026
概括
口腔癌中的细胞内细菌通过改变免疫反应影响免疫疗法. 像Fusobacterium这样的特定细菌与较差的结果有关,而某些免疫细胞可能预测治疗成功.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 新辅助性免疫检查点阻断 (NICB) 在口腔状细胞癌 (OSCC) 中表现有前途.
- 细胞内微生物群在NICB期间调节瘤微环境中的作用尚不清楚.
研究的目的:
- 在NICB期间调查细胞内细菌在OSCC瘤微环境中的宿主免疫反应的影响.
- 识别与NICB疗效和耐药性相关的细菌特征和宿主免疫细胞标记物.
主要方法:
- 使用侵袭-粘附导向表达序列 (INVADEseq) 来同时对宿主单细胞RNA和细菌特征进行分析.
- 分析了免疫基因表达,抗原呈现和免疫细胞激活对细胞内细菌的反应中的变化.
主要成果:
- 发现细胞内细菌可以抑制PDCD1的表达,增强感染反应,促进巨细胞的激活,并抑制T细胞相关的免疫力.
- 杆菌,菌和Capnocytophaga属与增加的风险和不良免疫治疗结果有关.
- GZMK+ CD8+ T细胞和ZBTB16+ TAMs作为对NICB完全反应的标记物出现.
- 细胞内细菌会损害cDC1和关键免疫细胞之间的通信,这可能会限制治疗效益.
结论:
- 细胞内细菌在OSCC中显著影响宿主对NICB的免疫反应.
- 特定的细菌系对免疫疗法构成风险,而已识别的免疫细胞种群可以预测治疗成功.
- 了解这些相互作用对于开发克服细菌介导的NICB耐药性的策略至关重要.
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