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通过厚度振动模式的高频超声波诱导的细胞内活性氧物种生成

Kotaro Fujishiro¹, Satoshi Okada², Filippo Rossi³

¹Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo, Japan.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|February 21, 2026

概括

高频超声波 (6.5 MHz) 能够有效地产生比传统超声波 (1 MHz) 更多的细胞内反应性氧物种 (ROS). 这一发现突显了高频超声波的重要性.

科学领域:

生物医学工程生物医学工程
细胞生物学细胞生物学
声学声学在声学上.

背景情况:

活性氧物种 (ROS) 是细胞中至关重要的信号分子.
超声波辐射可以产生ROS,但高频超声波的作用往往被忽视,因为化有限.
通过高频超声波研究ROS生成对于理解其细胞效应至关重要.

研究的目的:

为了比较由高频 (6.5 MHz) 和常规 (1 MHz) 超声波诱导的细胞内ROS生成.
阐明高频超声波在细胞ROS生产中的功能.

主要方法:

使用尼酸盐传感器进行超声波照射.
在溶液中的ROS生成和在6.5MHz和1MHz频率的细胞内生成进行比较.
在细胞水平上评估ROS的产生.

主要成果:

与1.0 MHz超声波相比,6.5 MHz超声波产生了显著更多的细胞内ROS.
高频超声波在ROS生产中显示出高空间分辨率.
6.5 MHz的超声波在产生细胞内ROS时被证明是有效的.

结论:

高频超声波能够有效地产生细胞内ROS.
高频超声波的空间分辨率可以在细胞水平上精确地诱导ROS.
这项研究为通过ROS调制在蜂应用中使用高频超声波开辟了新的可能性.

关键词:

高频超声波是一种高频超声波.一个基基的氧基.尼奥酸是一种酸.有活性氧物种的反应性氧物种.厚度振动模式振动模式

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