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Updated: Feb 23, 2026

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
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Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines

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通过链接特异性电荷调制来分离α2,3-和α2,6-化N-甘氨酸的制剂性分离

Qing Zhang1, Yi Lasanajak2, Guitao Bai3

  • 1Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Carbohydrate research
|February 21, 2026
PubMed
概括

研究人员开发了一种基于电荷的新型分离方法,用于化甘氨酸,区分α2,3-和α2,6-链接. 这种技术可以有效地隔离这些关键的生物分子,用于进一步的功能性糖化合物研究.

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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
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