SELE与乳腺癌易感性降低有关:来自孟德尔随机化和单细胞转录组的证据
Hanghang Chen1, Weihua Hu1, Ruidong Liu1
1Breast Surgery, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China.
Translational oncology
|February 21, 2026
概括
这项研究确定了循环中的蛋白质SELE,CDH1和ALPI与降低乳腺癌 (BC) 风险有因果关系. 研究结果表明,BC早期诊断和治疗的潜在新生物标志物和治疗点.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 蛋白质组学是指蛋白质组学.
- 癌症生物学 癌症生物学
背景情况:
- 循环蛋白在早期乳腺癌 (BC) 检测中的作用尚不清楚.
- 研究基因预测的蛋白质与BC风险的关联对于识别新生物标志物至关重要.
研究的目的:
- 通过综合性多omics方法识别乳腺癌 (BC) 早期诊断的新型蛋白质生物标志物.
- 通过孟德尔随机化 (MR) 调查循环蛋白和BC风险之间的遗传预测关联.
主要方法:
- 采用双样本的门德尔随机化 (MR) 框架来评估基因决定的循环蛋白与BC风险的关联.
- 大规模的蛋白质定量特征位点 (pQTL) 和全基因组关联研究 (GWAS) 数据被整合,通过交叉验证,敏感性分析和元分析来加强分析.
- 进行了遗传局部化,分子对接和全现象MR (PheWAS-MR),以及批量和单细胞RNA测序分析.
主要成果:
- 三种循环蛋白SELE,CDH1和ALPI与降低BC风险有关.
- CN জৈTP2与BC风险增加有关.
- 在BC组织内皮细胞中,SELE的表达显著降低,SELE在123种表型中表现出广泛的类效应.
结论:
- 强有力的遗传证据支持SELE,CDH1和ALPI在降低乳腺癌风险方面的因果作用.
- 综合性蛋白质基因转录基因方法提供了潜在的治疗点和对BC病变的新见解.
- 研究结果为未来的临床验证提出了假设,并强调了SELE作为生物标志物和治疗点的潜力.
更多相关视频
06:24Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
Published on: March 12, 2021
4.2K
08:53Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
15.1K
相关概念视频
02:21Cancers Originate from Somatic Mutations in a Single Cell
15.0K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.0K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
9.9K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.9K