怀孕早期血清金属暴露与早产之间的关联:通过炎症性血细胞参数的调解
Wenjun Yao1, Luodan Zhang2, Ziyi Wang1
1Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui 230032, China.
Journal of hazardous materials
|February 21, 2026
概括
怀孕早期对等金属的暴露与早产 (PTB) 有关. 炎症标志物,如白细胞 (WBC) 和中性粒细胞 (NE) 计数,调解这种关联,提供了对PTB机制的见解.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 过早分娩 (PTB) 是一个重要的全球健康问题.
- 在怀孕早期接触金属与PTB之间的联系机制尚不清楚.
- 炎症过程与不良妊娠结果有关.
研究的目的:
- 调查炎症性血细胞计数在早期怀孕金属暴露和PTB之间的关系中扮演的调解角色.
- 评估多种金属对PTB风险的综合影响.
- 为了识别特定的金属和炎症标记物参与金属-PTB通路.
主要方法:
- 量子g计算 (Q-gcomp) 和贝叶斯核机器回归 (BKMR) 用于组合金属效应.
- 对于单个金属-PTB和金属血细胞计数协会的线性和逻辑回归.
- 调解分析用于评估血细胞计数 (WBC,NE) 的作用.
主要成果:
- (Ba), (Pb) 和 (Cd) 的血清水平与PTB风险有积极的相关性.
- 白细胞 (WBC) 和中性粒细胞 (NE) 计数介导了血清Ba暴露和PTB之间的关联.
- 较高的整体金属暴露与PTB风险增加有显著的联系.
结论:
- 妊娠早期的血清Ba暴露与PTB的风险增加有关.
- WBC和NE计数在Ba暴露与PTB关系中起到调解作用.
- 研究结果提供了有关金属暴露如何导致PTB的机制性见解.
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