相关实验视频

Updated: Feb 23, 2026

Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites
05:28

Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites

Published on: June 2, 2023

1.4K

发现了具有强大的Nrf2激活活性的新型Keap1向性疏水标签 (HyT) 连接降解剂

Zhiying Li1, Mingjie Liu1, Haiyang Zhao1

  • 1Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China.

European journal of medicinal chemistry
|February 21, 2026
PubMed
概括

研究人员开发了新的疏水性标签结合降解剂 (HyTTDs),以准Keap1,激活Nrf2抗氧化反应. 化合物NBE5显示出治疗诸如炎症性肠道疾病等与氧化还原相关疾病的前景.

关键词:
巴尔多克索隆 (Bardoxolone) 是一种疏水性标签是一种疏水性标签.炎症性肠病是一种炎症性肠病.凯普1号码是什么意思Nrf2 激活方式有针对性的蛋白质降解降解.

更多相关视频

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

11.2K
Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA10:21

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

Published on: February 23, 2024

3.8K

相关概念视频

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.1K